The bacterium Borrelia burgdorferi and, in rare cases, Borrelia mayonii are the culprits behind Lyme disease. Through the bite of infected blacklegged ticks, it is transferred to people. Fever, headaches, exhaustion, and the distinctive skin rash known as erythema migrans are typical symptoms. Joints, the heart, and the nervous system can all get infected if untreated. The potential of exposure to infected ticks, physical signs (such as a rash), and symptoms all contribute to the diagnosis of Lyme disease. If carried out properly and according to proven procedures, laboratory testing is beneficial. A few weeks of medicines can successfully treat the majority of Lyme disease cases. Use of insect repellent, early tick removal, pesticide application, and reduction of tick habitat are measures to prevent Lyme disease.