Autoinflammatory Diseases
The autoinflammatory disorders are a set of illnesses that, in their most basic manifestations, show up as recurring fevers, strong acute phase reactions, and a tendency toward skin, joint, and serosal surface inflammation as well as other organ involvement, including nervous system involvement. These conditions don't have high-titer autoantibodies, which are typical of autoimmune diseases. Autoinflammatory disorders are characterized by dysregulation of the cells and molecular cascades essential to innate immunity, and this dysregulation is the primary pathophysiologic role of the innate immune system in these diseases.